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Rawhide-based oral hygiene chews are chews with an abrasive texture that can help prevent or delay the formation of dental plaque and calculus build-up on your pet’s teeth. C.E.T.® Enzymatic Oral Hygiene Chews is one common brand.
The U.S. Food and Drug Administration (FDA) does not review non-drug health products (e.g., herbals, nutraceuticals, shampoos, and other supplements) for safety or effectiveness before they are sold to the public. Manufacturers of non-drug health products must ensure their products are safe and labeled accurately.
The FDA requires that these non-pharmaceuticals contain a disclaimer that says, “This product is not intended to diagnose, treat, cure or prevent any disease.” Health Canada licenses “veterinary health products” after reviewing safety, efficacy, and manufacturing information provided by the manufacturer. These products are not tested by Health Canada.
Your veterinarian is the best source of information about the safety of non-drug health products in pets. Just because a product is natural does not mean it is safe. All medicines and medicinal plants are potentially toxic if used inappropriately or given at high doses. Supplements can also have side effects, like pharmaceuticals. Few supplements and herbs have been subjected to rigorous scientific trials to determine their efficacy.
Although the information in this handout may be helpful, it may also be incomplete and may not represent the full range of effects the supplement could have on your pet.
This supplement can take several days to show effects within the body. Visible improvements are not always evident.
If you miss a dose, give it as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed dose and resume the regular dosing schedule. Do not give the pet two doses at once.
Rawhide-based oral hygiene chews may cause the following side effects:
Sensitivities can develop over time, with repeated exposure. Your pet may have no reaction after the first few doses but may develop a sensitivity later. It is important to watch for signs of an allergic reaction each time this medication is used.
Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. Rawhide-based oral hygiene chews are short-acting supplements that stop working within 24 hours, but effects may be prolonged in pets with liver or kidney disease.
DO NOT USE rawhide-based oral hygiene chews in pets that:
USE WITH CAUTION in:
There are no documented drug interactions with this supplement. Be sure to tell your veterinarian about any medications (including vitamins, supplements or herbal therapies) that your pet is taking before starting any treatment.
If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility. Be prepared to provide information about the product and your pet's weight and symptoms. Adverse effects should also be reported to the FDA or Health Canada.
© Copyright 2025 LifeLearn Inc. Used and/or modified with permission under license. This content written by LifeLearn Animal Health (LifeLearn Inc.) is licensed to this practice for the personal use of our clients. Any copying, printing or further distribution is prohibited without the express written consent of LifeLearn. This content does not contain all available information for any referenced medications and has not been reviewed by the FDA Center for Veterinary Medicine, or Health Canada Veterinary Drugs Directorate. This content may help answer commonly asked questions, but is not a substitute for medical advice, or a proper consultation and/or clinical examination of your pet by a veterinarian. Please contact your veterinarian if you have any questions or concerns about your pet’s health. Created on May 15, 2025.
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